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p60-HCK
Definition and Synonyms

Definition: May serve as part of a signaling pathway coupling the FC receptor to the activation of the respiratory burst. Furthermore, it may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils. p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK. Both are expressed predominantly in cells of the myeloid and b-lymphoid lineages, thus also called B-cell/Myeloid kinase. Contains 1 sh2 domain and 1 sh3 domain. Has been mapped to chromosomal location 20q11-q12.

Synonyms: p60-HCK, B-cell/myeloid kinase, Hemopoietic Cell Kinase p60

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