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KAI1 Gene
Definition and Synonyms

Definition: Expressed in many tissues, the 80 kb human KAI1 Gene (TM4SF family) at 11p11.2 contains ten exons that specify metastasis suppressor KAI1 Protein, with four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2, similar to CD37 and CD53. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)

Synonyms: KAI1 Gene, 4F9, C33, CD82, CD82 Gene, GR15, IA4, KAI1, R2, SAR2, ST6

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