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MAFG Gene
Definition and Synonyms

Definition: Widely expressed human MAFG Gene (MAF family) at 17q25 contains at least three exons separated by small introns and an untranslated first exon. Highest expression of the encoded bZIP transcription factor appears in skeletal muscle. Lacking a transactivation domain, MAFs seem to be homodimerized repressors and heterodimerized activators with other bZIP proteins. MAFG Protein heterodimerizes with NFE2/CNC Family members: NRF1, NRF2 and p45NFE2. NFE2 enhancers upstream of alpha- and beta-globin genes regulate globin expression and erythroid differentiation through DNA-binding of a heterodimeric MAF protein (MAFF, MAFG, or MAFK) complexed with tissue-restricted p45NFE2. MAF proteins also heterodimerize with FOS and may repress NFE2 as well. (from SWISS-PROT, OMIM, and NCI)

Synonyms: MAFG Gene, MAFG

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