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E2F1 Gene
Definition and Synonyms

Definition: The E2F1 gene at 20q11.2 encodes E2F1, which binds DNA as homo- or heterodimers with DP1 or DP2. E2F1 transactivates p53 and p73. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner through accumulation of p73 or through a death receptor-dependent mechanism by down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 also induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB-E2F repression mediates G1 arrest triggered by TGFB, by p16, and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. (from OMIM 189971 and NCI)

Synonyms: E2F1 Gene, E2F-1, E2F1, RBBP3, RBP3

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