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MADH4 Gene
Definition and Synonyms

Definition: Between D18S1118 and D18S487, human MADH4 Gene (Dwarfin/SMAD family) at 18q21.1 contains eleven exons and is a cloned gene for Juvenile Polyposis and associated with colon cancer. Critical for transmitting TGFB and related cytokine signals to the nucleus for target gene activation, the encoded SMAD4 tumor suppressor protein recognizes an eight base pair palindromic DNA regulatory sequence. (from SWISS-PROT, OMIM, and NCI)

Synonyms: MADH4 Gene, DPC4, MAD Homolog 4 Gene, MADH4, Mothers Against Decapentaplegic Homolog 4, SMAD4, SMAD4/DPC4 Gene

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