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Hamartin
Definition and Synonyms

Definition: A product of the tumor suppressor gene TSC1. Hamartin and tuberin (TSC2) associate physically and may function together in the insulin-signaling pathway. Hamartin may stabilize ubiquitinated tuberin, which contributes to inhibition of cell growth. Loss of hamartin leads to loss of cell adhesion and initiates the development of TSC hamartomas. (from OMIM 605284 and NCI)

Synonyms: Hamartin, TSC1

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