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B-Cell CLL Lymphoma-3
Definition and Synonyms

Definition: A possible transcriptional activating factor, BCL3 is activated by phosphorylation and functions as an IKB specific for the p50 subunit of NFKB, inhibiting its translocation to the nucleus. BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members. Translocation t(14;19)(q32;q13.1), involving BCL3 and immunoglobulin gene regions, is associated with B-CLL. (from OMIM 109560 and NCI)

Synonyms: B-Cell CLL/Lymphoma 3, B-Cell Lymphoma 3-Encoded Protein, BCL-3 Protein, BCL3, BCL4, D19S38

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