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p300 CBP-Associated Factor
Definition and Synonyms

Definition: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. p300/CBP-Associated Factor, encoded by the PCAF gene, displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)

Synonyms: p300/CBP-Associated Factor, CREBBP-Associated Factor, EC 2.3.1.-, Histone Acetylase PCAF, P/CAF, PCAF

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