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Kangai-1 Protein
Definition and Synonyms

Definition: Kangai 1 Protein, a metastasis suppressor protein encoded by the 80 kb human KAI1 gene (TM4SF family), is expressed in many tissues and has four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down-regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)

Synonyms: Kangai 1 Protein, Antigen CD82, C33 Antigen, CD82 Antigen, IA4, Inducible Membrane Protein R2, KAI1, KAI1 Protein, Leukocyte Surface Antigen R2, Metastasis Suppressor Kangai 1, Prostate Cancer Antimetastasis Gene Kai1, R2 Leukocyte Antigen, R2 Leukocyte Surface Antigen, Suppressor of Tumorigenicity 6, Suppressor of Tumorigenicity-6

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