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E1A Binding Protein-p300
Definition and Synonyms

Definition: Important in cell proliferation and differentiation, E1A-Associated p300 Protein is a histone acetyltransferase and transcriptional co-activator/integrator that regulates transcription via chromatin remodeling. p300 contains a bromodomain, a KIX domain, and three Cys/His-rich regions. A compact IBID domain in p300 participates in ligand binding and contributes to signal integration by p300. LIF and BMP2 cytokines signal through STATs and SMADs, respectively, and act in synergy on progenitor cells to induce astrocytes. p300 interacts with STAT3 in a cytokine-independent fashion, and with SMAD1 in a cytokine-dependent manner. The formation of a p300-bridged complex between STAT3 and SMAD1 mediates cooperative LIF/BMP2 signaling and astrocyte induction. p300 also facilitates DNA repair by PCNA via chromatin remodeling at DNA lesions. p300 forms an S phase-independent complex with PCNA that stimulates DNA synthesis. (from OMIM 602700 and NCI)

Synonyms: E1A Binding Protein p300, E1A-Associated Protein p300, E1A-Associated p300 Protein, E1A-Binding Protein, 300kD, EC 2.3.1.48, EP300, p300, p300 E1A-Associated Coactivator

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