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I-Kappa-B-Alpha Protein
Definition and Synonyms

Definition: Encoded by glucocorticoid-inducible human NFKBIA Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha contains 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NFKB in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and for rapid degradation via the ubiquitin system. (NCI)

Synonyms: I Kappa B-Alpha Protein, I Kappa B A, I Kappa B Alpha, I Kappa B-Alpha, I-Kappa-B-Alpha, IKB-Alpha, IKBA, IKappaB, IKappaB-Alpha, IKappaB/MAD-3, Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha, MAD-3, MAD3, Major Histocompatibility Complex Enhancer-Binding Protein MAD3, NF-Kappa B Inhibitor Alpha, NFKBI, NFKBIA, Nuclear Factor Kappa-B Inhibitor, Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha, Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha

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