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p59-FYN
Definition and Synonyms

Definition: p59-FYN contains an SH2 and an SH3 domain, is a SRC/YES-related tyrosine kinase expressed in various cell types, and is implicated in the control of cell growth. FYN is quickly activated after mIg cross-linking on B-cells or TCR cross-linking on T-cells. FYN associates, through its SH3 domain, with PI3-kinase p85 subunit and interacts with FYN-binding protein FYB. Upon induction of the murine 1C11 clone by PrPc-dependent signal transduction, epithelial cells develop a neural-like morphology and differentiate into either serotonergic or noradrenergic cells, depending on stimulus. Phosphorylation of FYN is linked to ligation of PrPc, the cellular, nonpathogenic isoform of prion protein, a ubiquitous glycoprotein expressed strongly in neurons. The coupling of PrPc to FYN is dependent upon caveolin-1. (from OMIM 137025, Swiss-Prot P06241, and NCI)

Synonyms: p59-FYN, FYN, FYN Protein

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