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E2F Transcription Factor-1
Definition and Synonyms

Definition: Transcription factor E2F1 binds to DNA as homo or heterodimers with DP1 or DP2. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (from OMIM and NCI)

Synonyms: E2F Transcription Factor 1, E2F-1, E2F1, PBR3, PRB-Binding Protein E2F-1, RBAP-1, RBBP-3, Retinoblastoma Associated Protein 1, Retinoblastoma Binding Protein 3, Retinoblastoma-Associated Protein 1, Transcription Factor E2F

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