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ABL1 Tyrosine Kinase
Definition and Synonyms

Definition: ABL1 tyrosine kinase has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1 tyrosine kinase. (from LocusLink)

Synonyms: ABL1 Tyrosine Kinase, ABL Tyrosine Kinase, ABL1, P150, Proto-Oncogene Tyrosine -Protein Kinase ABL, c-ABL Protein

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