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O-6-Methylguanine-DNA Methyltransferase
Definition and Synonyms

Definition: Encoded by human MGMT Gene (MGMT Family), 207-aa 22-kDa O-6-Methylguanine-DNA Methyltransferase is a unique and ubiquitous DNA repair enzyme that acts on alkylated guanine and other methylated DNA moieties. O(6)-alkylguanine is the major mutagenic and carcinogenic adduct lesion in DNA, induced by simple alkylating mutagens because of its preference for pairing with thymine during DNA replication. Unlike true enzymes, MGMT accepts the O-6 alkyl group from the lesion to a cysteine acceptor residue in the enzyme repairing the alkylated DNA in a stoichiometric second-order suicide reaction; the enzyme is irreversibly inactivated. (NCI)

Synonyms: O-6-Methylguanine-DNA Methyltransferase, AGT, Alkylguanine DNA Alkyltransferase, DNA-6-O-Methylguanine[protein]-L-Cysteine S-Methyltransferase, EC 2.1.1.63, MGMT, Methylated-DNA Protein-Cysteine Methyltransferase, Methylguanine-DNA Methyltransferase, O6-Alkylguanine DNA Alkyltransferase

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