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E-Cadherin
Definition and Synonyms

Definition: Encoded by human CDH1 Gene (CDH Family), 882-amino acid 97 kD (precursor) invasion suppressor type I membrane protein E-Cadherin is the main homodimeric Ca(2+)-dependent cell-cell adhesion glycoprotein in non-neural epithelia. Structurally similar to immunoglobulins, E-cadherin contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail required for internalization. E-Cadherin acts as ligand for integrin Alpha-E/Beta-7. CDH1 defects cause Familial Gastric Cancer. CDH1 mutations are correlated with breast, colorectal, thyroid, and ovarian cancer. E-cadherin down regulation often correlates with invasive potential and poor prognosis of human carcinomas; it is likely a main event in cancer proliferation, invasion, and metastasis, due to dysfunction of cell-cell adhesion. (from LocusLink, SWISS-PROT, OMIM, and NCI)

Synonyms: E-Cadherin, CAM 120/80, CDH1, Cadherin-1, Epithelial Calcium-Dependent Adhesion Protein, Epithelial-Cadherin, Uvomorulin

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