Are All Dementias Alzheimer’s? by Michael G. Rayel, MD

Impairment in executive functioning is characterized by difficulty in abstract reasoning and in organizing things, schedule, and activities. Patients with this problem give concrete meaning to proverbs. For example, when a patient is asked what “don’t cry over spilled milk” means, the patient responds, “It’s easy. Just wipe it!” Moreover, knowing the specific similarities and differences of certain things (e.g. apple versus orange) is a struggle for some patients.

What are the possible causes of Alzheimer’s?

The cause of Alzheimer is still unknown. However, several risk factors have been identified. One major risk factor is age. The risk of developing dementia increases as our age advances. Older individuals therefore are more at risk. Having said this, Alzheimer’s can also happen to young individuals.

Other important risk factors include the presence of apolipoprotein E4 allele, the predominance of plaques and tangles in the brain, and the brain’s impaired cholinergic system.

Is there any successful treatment for Alzheimer’s?

Alzheimer’s disease is irreversible so current medications are only geared to slow down the deterioration. These acetylcholisterase inhibitors, namely galantamine, rivastigmine, and donepezil, are aimed at improving the cholinergic functioning in the brain by inhibiting the cholinesterase enzyme. Although initially indicated for mild to moderate dementia, some recent evidence shows that some of these drugs may also benefit patients with moderate to severe dementia. Further studies are warranted to determine its efficacy in this group.

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BIO:

Copyright©2004. All rights reserved. Dr. Michael G. Rayel – author (First Aid to Mental Illness–Finalist, Reader’s Preference Choice Award 2002), psychiatrist, and inventor of Oikos Game: A Personal Development and Emotional Skills Game. Please visit www.oikosgame.com for more information.

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